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6% [39 of 77]). A majority of laboratories used benchtop sequencers and custom enrichment approaches. This manuscript summarizes the characteristics of clinical NGS-based testing for the detection of somatic variants in HM. These data may be broadly useful to inform laboratory practice and quality management systems, regulation, and oversight of NGS testing, and precision medicine efforts using a data-driven approach. This manuscript summarizes the characteristics of clinical NGS-based testing for the detection of somatic variants in