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Transthyretin (TTR) gene mutations would be the most typical cause of genetic amyloidosis. Valine changed by isoleucine constantly in place 122 (V122I) variant is common, particularly in the black populace. Carriers of V122I have increased threat for developing cardiac amyloidosis. Despite a relatively high prevalence, the penetrance of V122I is not securely established. This research desired to determine the prevalence of medically app