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falciparum. In molecular docking studies, both compounds bind into the active site of PfFP-2 and block its accessibility to the substrate that leads to the inhibition of target protein further supported by in-vitro analysis. Overall, we report antimalarial potential of triazole-amino acid hybrids and their role in the inhibition of cysteine protease PfFP-2 as its mechanistic aspect. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] cycadina has diverse traditional uses in