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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are first-choice ADHD drugs, have the most research-based backing behind them, and they are quick-acting. However, they're not suitable for everyone. These medications increase the signaling between nerves and regions in the brain to lessen symptoms of ADHD. can also trigger adverse effects such as a change in blood pressure or heart rate and a loss of appetite. Stimulants The most frequently used medication to treat ADHD