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We propose that the proteasome-stimulating TAT pharmacophore provides an attractive lead for future clinical use.In this study, we aimed to determine the synergistic effects of a formula consisting of dried pomegranate concentrate powder, Eucommiae Cortex, and Achyranthis Radix 541 (g/g) (PCPECAR) in a surgically induced osteoarthritis (OA) rabbit model. PCPECAR was orally administered once per day. Knee thickness, maximum extension of the knee joint, gross articular defect area, and the histopathological appearance of the cartilage were m