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To evaluate the factors that could influence the fracture resistance of implant-supported posterior monolithic zirconia crowns. Sixty zirconia molar crowns with three different occlusal thicknesses of 0.5, 1.0, and 1.5 mm (20 samples per group) were prepared for implant abutments using a CAD/CAM system. In each group, 10 crowns were luted on the abutment with resin cement (Panavia F), and the other 10 crowns were luted with resin-modified glass-ionomer cement (Ketac Cem Plus). Dynamic loading (1.2 × 10 cycles; 70 N) and thermal cycling