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Background Previous studies demonstrated the critical role of miRNAs in carcinogenesis. Aberrant expression of miR-127-3p and miR-144-3p have been revealed in several types of cancers. Methods Expression levels of miR-127-3p and miR-144-3p were detected in the plasma of patients with gastric cancer (GC) using fluorescent quantitative polymerase chain reaction to recognize potential non-invasive biomarkers for GC and evaluated the relationship between their expression and clinicopathological parameters of GC. Results The results showed mi