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Achieving combination of spin and valley polarized states with topological insulating phase is pregnant to promote the fantastic integration of topological physics, spintronics and valleytronics. In this work, a spin-valley-coupled quantum spin Hall insulator (svc-QSHI) is predicted in Janus monolayer CSb1.5Bi1.5with dynamic, mechanical and thermal stabilities. Calculated results show that the CSb1.5Bi1.5is a direct band gap semiconductor with and without spin-orbit coupling, and the conduction-band minimum and valence-band maximum are a