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With increasing level of ESBM in the diet, starter intake increased quadratically during the pre-weaning period (p less then 0.05) and body weight, DM intake and average daily gain increased linearly during the post-weaning and the whole study period (p less then 0.05). Dry matter and CP digestibilities at week 14 and blood glucose and BHBA increased linearly in calves as the level of ESBM increased in the diet (p less then 0.05). Conclusion Dairy calves performance and physiological responses were sensitive to SBM protein characteristics