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th both types of STCs. Both eSTCs and mSTCs were represented by cells with different stem and/or EMT phenotypes. Conclusions STCs with epithelial-like morphology contribute to breast cancer metastasis and represent an attractive model for studying mechanisms of metastatic seeding. The assessment of STCs in histological sections of breast tumors can be a simple and effective method for the prediction of metastasis risk. Copyright © 2020 Tashireva, Zavyalova, Savelieva, Gerashchenko, Kaigorodova, Denisov and Perelmuter.Introduction Colon