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KPF attenuated the Cisplatin mediated apoptosis via down-regulating the levels of TP53, Bax/Bcl2 imbalance, activating caspase-3/9 and PARP. The outcome conclude that KPF ameliorates Cisplatin-mediated nephrotoxicity by modulating oxidative tension, swelling and apoptosis via ERK and NF-κB pathway.In purchase to determine genetics involved in the improvement inner ear hair cells, we investigated the part regarding the transcription element Islet-class LIM-homeodomain (LIM-HD