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03]. Satiation (VTF and MTV), GA as well as plasma levels of GLP1, GIP and HPP did not differ between treatment arms in health or FD. On ANCOVA analysis (adjusting for age and gender); secretin did not consistently increase postprandial symptoms in health or FD. Secretin delayed gastric emptying in both health and FD without significantly altering GA, VTF, or MTV or selected hormones. Thus, secretin receptor activation may provide a novel therapeutic mechanism for patients with FD and rapid gastric emptying.Purpose Primary aldosteronism (