https://www.selleckchem.com/pr....oducts/brr2-inhibito
The misfolding avoidance hypothesis postulates that sequence mutations render proteins cytotoxic and therefore the higher gene expression the stronger operation of selection against substitutions. This translates into prediction that relative toxicity of extant proteins is higher for those evolving faster. In the present experiment, we selected pairs of yeast genes which were paralogous but evolving at different rates. We expressed them artificially to high levels. We expected that toxicity would be higher for ones bearing mor
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