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Humans with biallelic inactivating mutations in Epithelial Cell Adhesion Molecule (EpCAM) develop congenital tufting enteropathy (CTE). To gain mechanistic ideas regarding EpCAM purpose in this disorder, we prepared abdominal epithelial cell (IEC) organoids and spheroids. IEC organoids and spheroids had been created from ROSA-CreERT2 EpCAMfl/fl mice. Expansion, tight junctions, cell polarity and epithelial integrity were considered in tamoxifen-induced EpCAM-deficient organoids via confocal immunofluorescence m
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