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© American Society of Regional Anesthesia Pain Medicine 2020. No commercial re-use. See rights and permissions. Published by BMJ.High rates of glycolysis in cancer cells are a well-established characteristic of many human tumors, providing rapidly proliferating cancer cells with metabolites that can be used as precursors for anabolic pathways. Maintenance of high glycolytic rates depends on the lactate dehydrogenase-catalyzed regeneration of NAD+ from GAPDH-generated NADH because an increased NADHNAD+ ratio inhibits GAPDH. Here, using human breast can
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