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Adolescent narcolepsy patients exhibited disrupted small-world network properties. Regional alterations in the caudate nucleus and posterior cingulate gyrus were associated with subjective sleepiness and regional alterations in the caudate nucleus and inferior occipital gyrus were associated with impulsiveness. Remodeling within the salience network and the default mode network was associated with sleepiness, depressive feelings and impulsive behaviors in narcolepsy. CONCLUSIONS Alterations in brain connectivity and regional topological