https://www.selleckchem.com/Proteasome.html
Mechanistically, we found that sublethal heat treatment increases epidermal factor growth receptor (EGFR) m A modification in the vicinity of the 5' untranslated region and promotes its binding with YTHDF1, which enhances the translation of EGFR mRNA. The sublethal-heat-induced up-regulation of EGFR level was further confirmed in the IRFA HCC PDX mouse model and patients' tissues. Combination of YTHDF1 silencing and EGFR inhibition suppressed the malignancies of HCC cells synergically. The m A-YTHDF1-EGFR axis promotes HCC progression after I
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