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The method is linear in the 0.025-2.5 μg/mL concentration range; the attained limit of quantification is in the range 18.3-22.8 nmol/L; the within-day precision for the migration time is 0.8-1.2% and for the peak area 1.5-2.4%.A membrane-based solid phase extraction (SPE)-ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the determination of nine glucocorticoids in water. This new hybrid SPE approach involved the deposition of sodium dodecyl sulfate (SDS)-multi-walled carbon na