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Compared with the control, hypoxic MSCs reduced brain water content significantly (p 0.05). Both hypoxic and normoxic MSCs downregulated the expression of MMP9 and normalized AQP4 distribution to astrocyte end feet. Our preliminary study showed that topical application of hypoxic MSCs suppressed both vasogenic and cytotoxic edema formation. Our preliminary study showed that topical application of hypoxic MSCs suppressed both vasogenic and cytotoxic edema formation. Previous eye-tracking studies provide preliminary evidence for a hyp