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To elucidate the pathogenesis of PH, several concepts targeting pulmonary artery smooth muscle cells (PASMC), such as for example hyperproliferation, resistance to apoptosis, and cancer tumors theory, are suggested and commonly examined. Right here, we attempted to summarize the research, concentrating on the part of PASMC within the growth of PH, possible molecular basis to intervene, and potential therapy to PH. The current research highlighte
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