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A new application of stimulated Raman scattering (SRS) uses the benefit of a label-free molecular fingerprint to image the uptake and distribution of an alkyne-based drug in living cells. This method delivers information on cellular molecular composition and drug-cell interaction, showing the potential of SRS in drug development.Bimolecular nucleophilic substitution (SN2) reactions are of great importance in chemistry and biochemistry due to their capability of constructing functional groups. In this work, we investigate the solvent eff
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