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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the most popular ADHD treatment, since they're the most studied and have the fastest-acting effects. But they're not for everyone. These medications enhance the signaling between nerves and brain regions to decrease ADHD symptoms. They can also cause side effects like the loss of appetite or changes in heart rate or blood pressure. Stimulants The most common medication used to treat ADHD is stimulants. They're known for enhancin