https://cc-5013chemical.com/th....e-consequence-involv
Herein, employing site-directed mutagenesis, allelic exchange, quantitative PCR analyses, immunoblotting and 13C-heme uptake experiments, we delineated the differential contributions associated with the extracellular FRAP/PNPNL loop residue His-624 in HasR and of His-221 in its N-terminal connect domain required for heme capture to heme transport and signaling, correspondingly. Especially, we show that substitution for the N-terminal connect His-221 disrupts both signaling and transport, leading to dysreg
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