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RESULTS No PrEP intervention scenarios were cost-effective for both age-groups at a willingness-to-pay threshold of $1,175/DALY averted. The lowest ICER ($2,873/DALY averted) was for the provision of oral PrEP to older men, although probability of cost-effectiveness was just .26%. Results found that ICERs were sensitive to HIV incidence and antiretroviral coverage. CONCLUSION This study estimates that providing PrEP to heterosexual South African men is not cost-effective at current cost-effectiveness thresholds. Given the ICERs' sensitivi