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The typical decrease in sIgG4 was 5.55±5.03. After Spearman's rank correlation test, ESR, sIgG4, and sIgG were independently associated with reduction of sIgG4 (p.05) and were chosen as input factors. Account for these parameters, BP-ANN design was developed additionally the coefficient of dedication (roentgen The BP-ANN design predicated on ESR, sIgG4, and sIgG could predict the 3-month reduced total of sIgG4 for IgG4-DS patients. It revealed possible medical application worth.Th