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05), Mendelian randomization study was failed to prove the association between IL-18 level and CVD risk. CONCLUSION This study does not support a causal association between IL-18 level and the risks of CVD.BACKGROUND Aim of the present study is the evaluation of ultrasound as a physical method for virus inactivation in human plasma products prior to transfusion. Our study is focused on achieving a high level of virus inactivation simultaneously leaving blood products unaltered, measured by the level of degradation of coagulation factors