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Conclusions The present study indicated that irisin or FNDC5 improved BM-MSC engraftment and paracrine effects in infarcted hearts, which could provide a possible therapeutic target for MI.Background The interleukin-6 receptor inhibitor sarilumab demonstrated efficacy in conjunction with traditional synthetic disease-modifying antirheumatic medicines (csDMARDs) or as monotherapy in patients with mildly to severely active rheumatoid arthritis (RA) with an inadequate reaction (IR) or intole