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Many studies demonstrated the upregulated expression of this entire signaling pathway in gynecological malignancies and some dedicated to the purpose of COX-2 and cAMP-linked EP2/EP4 and EP3 signaling path in gynecological disease. By comparison , roles of EP1 while the exact pathological mechanisms have not been completely clarified. The studies regarding EP receptors in gynecological cancers highlight the potential advantage of combining COX enzyme inhibitors with EP receptor