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ain range, which can be used to infer age. To determine the association between malocclusion and the severity of dental caries among children and adolescents in the permanent dentition. A search was conducted in Medline, Cochrane databases, Google scholar, Scopus and Web of Science through October 2020 for studies of malocclusion and dental caries among children and adolescents using the Dental Aesthetic Index (DAI) and the Decayed, Missing, Filled Teeth (DMFT) index. Quality was evaluated using the Newcastle-Ottawa tool for cross-sectional studies.