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Caffeine is detoxified by cytochrome P450 1A2 (CYP1A2), and hereditary variation in CYP1A2 impacts the rate of caffeine clearance. Factors which will alter the organization between coffee consumption and kidney infection remain confusing. To assess whether CYP1A2 genotype modifies the organization between coffee intake and kidney dysfunction. The Hypertension and Ambulatory tracking Venetia research (HARVEST) ended up being a potential cohort study of individuals with phase 1 hypertension i