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This study developed a domain-transform framework comprising domain-transform manifold learning with an initial analytic transform to accelerate Cartesian magnetic resonance imaging (DOTA-MRI). The proposed method directly transforms undersampled Cartesian k-space data into a reconstructed image. In Cartesian undersampling, the k-space is fully or zero sampled in the data-acquisition direction (i.e., the frequency-encoding direction or the x-direction); one-dimensional (1D) inverse Fourier transform (IFT) along the x-direction on the un