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All the patients received teriparatide as a second-line therapy. © 2020 Chen et al.Background Aging is a spontaneous and inescapable phenomenon of biology, which can lead to the progressive deterioration of areas and body organs. Among the age-related deterioration procedures is immunosenescence, which leads to alterations in the big event of resistant methods, including resistant cells and associated cytokines. A suitable modulation of immune responses can enhance the age-relate