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Collectively, this work provides a promising hTAAR1 antagonist probe that can be used to study TAAR1 pharmacology and the potential therapeutic role in hypodopaminergic diseases such as PD.The weak interfacial binding affinities of the inorganic perovskite core with ligands and high density of surface defect states induce the facile detachment of surface ligands from nanocrystals (NCs), resulting in their poor colloidal stability and fluorescence in aqueous. In this work, a powerful ligand engineering strategy was proposed for eliminatin