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ulanic acid. Four patients required multiple antibiotics and intrahospital care.Genes differ in the frequency at which they are expressed and in the form of regulation used to control their activity. In particular, positive or negative regulation can lead to activation of a gene in response to an external signal. Previous works proposed that the form of regulation of a gene correlates with its frequency of usage positive regulation when the gene is frequently expressed and negative regulation when infrequently expressed. Such network