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Higher CRF was associated with better episodic memory (Standardized β=0.391; p=0.008), EF (Standardized β=0.324; p=0.025), and visuospatial performance (Standardized β=0.570; p=0.005). Higher CRF was associated with larger thalamic (Standardized β=0.722; p=0.004) and pallidum (Standardized β=0.635; p=0.004) volumes. Thalamic volume mediated the association between higher CRF and better EF (Indirect effect=0.309) and episodic memory (Indirect effect=0.209) performance (p0.05). The pallidum did not significantly mediate associations b