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The treatment strategies for SSCDS continue to diversify. A patient-specific approach with systematic documentation of outcomes will continue to inform how these patients are best managed. Middle ear cholesteatoma is an epithelial lesion that expands into the middle ear, resulting in bone destruction. However, the pathogenesis of this has been unknown. The purpose of this review is to understand the role of keratinocyte growth factor (KGF) during epithelial stem and/or progenitor cell proliferation in middle ear cholesteatoma. Many resea
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