https://cxcrsignal.com/index.p....hp/part-of-toll-like
Histopathological modifications observed in murine hypopharyngeal mucosa confronted with acid bile had been preceded by the overexpression of Tnf, Il6, Bcl2, Egfr, Rela, Stat3, therefore the deregulation of miR-21, miR-155, miR-192, miR-34a, miR-375, and miR-451a. This is actually the first research to document that acidic bile is carcinogenic within the top aerodigestive tract. We indicated that oxidative DNA-damage generated by acid bile in combination with NF-κB-related anti-apop
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