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As a result, severe mildew developed on all five cucurbits, including bitter gourd, which expressed tolerance to the pathogen. Fungus colonization in terms of the number of conidia/cm2 leaf surface was significantly greater on the plants exposed to 500 or 600 ppm CO2. The stomata and trichome density and stomatal pore width were increased in the leaves of CO2 exposed plants. The CO2 exposures also accelerated the photosynthesis rate, but transpiration, stomatal conductance, salicylic acid and total phenols were decreased; fungus inocula