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RAO with multiple emboli is an important sign warning critical flow changes of carotid occlusions. Reversed ophthalmic flow indicates the presence of external carotid/ophthalmic collaterals as the source of ocular blood supply and the origin of emboli. In this case, all the embolic, hemodynamic, and serotonin mechanisms may be responsible for the pathogenesis. RAO with multiple emboli is an important sign warning critical flow changes of carotid occlusions. To report the clinical improvement observed in a glaucomatous patient affected