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BMI gain over the life course was positively associated with non-dense volume, but not dense volume. We observed strong associations between BMI change over the life course and mammographic breast density. The inverse associations between early life adiposity change and volumetric percent density suggest that childhood adiposity may confer long-term protection against postmenopausal breast cancer via its effect of mammographic breast density. Copyright ©2020, American Association for Cancer Research.Vitamin D may influence pro