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1. A LET15°C was recorded in 3/80 patients (4%) in the CB120 group and in 16/80 patients (20%) in the CB240 group (p.01). Composite rate of energy-related safety events (LET15°C and PN injury) was significantly lower in the CB120 (34%vs. 9%, p.01). Safety of second generation CB PVI can be increased using a double 120 s freeze protocol. Safety of second generation CB PVI can be increased using a double 120 s freeze protocol. The objective of this scoping review was to summarize, understand and provide an overview of t