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How Does Medication For ADHD Work? Stimulants increase levels of dopamine and norepinephrine within your brain, which can improve concentration and impulse control. They are available in immediate-release (short acting) and extended release tablets that can be taken once daily in the morning. Nonstimulant medications can help improve concentration and impulse control however, they take longer to work. Atomoxetine, Viloxazine and guanfacine are antidepressants that increase norepinephrine levels. Stimu