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Fennel (Foeniculum vulgare Mill.) is an herbal plant which has had anti-oxidant and neuroprotective properties. The objective of this research was to evaluate the effect of fennel methanol extract and its own significant element trans-anethole on spatial discovering and memory, anxiety and depression in male rats subjected to social separation stress.Rats were divided into six groups of Control (C), Fennel (F), trans-Anethole (A), Isolation, Isolation