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First Line Treatment For ADHD in Adults Certain people suffering from ADHD discover that medication can help to manage their symptoms. Stimulants such as methylphenidate or amphetamine help by enhancing brain activity in areas that control attention and behavior. Other medications, such as the non-stimulant drug atomoxetine and certain antidepressants perform differently, but are still effective. Regular visits to the GP are recommended for those who take medications. They can alte