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This study aimed to evaluate the effect of nanoparticles on the mechanical properties of acrylic denture repairs. The review was designed following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. Database search was conducted involving articles published from 2000 to 2020 using the following keywords PMMA/nanoparticles, denture repair/nanoparticles, and repair strength/nanoparticles. PubMed/MEDLINE, Embase, Google Scholar, Scopus, and EBSCOhost were used to find only those studies used repair resin