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Significance statement These findings broaden the general understanding of transcriptional regulation of intrinsic plasticity in learning and memory. Regulation of intrinsic plasticity has wide-ranging implications and fundamental importance for neurological diseases. Copyright © 2020 Atacho et al.Local brain signal variability (standard deviation of the BOLD signal [SDBOLD]) correlates with age and cognitive performance, and recently differentiated Alzheimer's disease (AD) patients from healthy controls. However, it is unknown if ch