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To our knowledge, we report the first case of percutaneous pulmonary thrombectomy and catheter directed thrombolysis for massive pulmonary embolism (PE) in a patient with presumed severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Standard treatments of anticoagulation and systemic thrombolysis were unsuccessful and the patient continued to deteriorate. Percutaneous pulmonary thrombectomy and locally delivered thrombolysis was a life‐saving treatment; the patient continues to improve and is currently being nursed on a standa