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Aim To identify the psychological change process of the registered nurses who worked in the epicenter of the COVID-19 outbreak.Background The pandemic of COVID-19 has continued to pose an unprecedented threat and challenge to people's health around the world. Nurses are at high risk because they work within the closest proximity to patients. Understanding nurses' psychological change process during the care for patients with COVID-19 is imperative for healthcare leaders.Methods This was a qualitative descriptive study that took place in