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Aerobic training is effective in reducing blood pressure in patients with type 2 diabetes, regardless of progression in training variables. To determine if HLA-DP loci independently contribute to classic type 1 diabetes (T1D) of all ages, childhood-onset T1D and latent autoimmune diabetes in adults (LADA) among Chinese Han population. A total of 518 patients with classic T1D (Among them 180 participants manifested T1D between 1 and 14years), 519 patients with LADA and 527 normal controls were genotyped for both HLA-DPA1 and -DPB1 loci.