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Although its antimicrobial activity is characterized, its impact on Candida albicans physiology remains becoming elucidated. The present study evaluated the influence of surfactin-C15 (SF) and its particular complexes with divalent counterions on C. albicans biofilm formation and preformed biofilms. The SF and metal(II)-SF complexes inhibited biofilm formation and decreased the metabolic activity of mature biofilms in a concentration-dependent fashion. E